Volume 1 ; Issue 1 ; in Month : Jan-June (2026) Article No : 106
Cai YL, Lina W, Wei C, et, al.

Abstract

Background: Ventilator-associated pneumonia (VAP) is a leading nosocomial infection in intensive care units (ICUs), associated with prolonged hospital stay, elevated medical expenses, and increased mortality. Effective oral care and airway management are critical strategies for VAP prevention. Objective: To evaluate the clinical efficacy of JUC long-acting physical antimicrobial material combined with standardized oral care in reducing VAP incidence, oral bacterial colonization, and respiratory tract infections in patients undergoing oral endotracheal intubation and mechanical ventilation. Methods: This integrated analysis combined data from two clinical controlled trials. A total of 120 mechanically ventilated patients were included, divided into routine oral care control groups and JUC intervention groups. The intervention groups received routine oral care combined with JUC antimicrobial spray, while control groups received routine oral care alone. Outcome measures included VAP incidence, oral bacterial count, oral infection, and halitosis. Results: Compared with the control group, the JUC intervention group showed a significant reduction in VAP incidence (from 33.3% to 6.7% and from 21.3% to 5.3%, respectively; P<0.05). Airway and oral bacterial counts decreased by more than 90% after JUC application. The occurrence of oral infection and malodor was also significantly lower in the intervention group. Conclusion: JUC long-acting physical antimicrobial material effectively inhibits bacterial colonization in the oral cavity and respiratory tract, significantly reduces VAP incidence, and improves airway hygiene. With no drug resistance and high safety, JUC is a reliable adjuvant therapy for VAP prevention in critically ill patients. Consistent with the conclusions of multiple recent systematic reviews, JUC’s physical bactericidal mechanism and long-acting antibacterial effect make it superior to traditional chemical antimicrobials in oral care for mechanically ventilated patients, and it is worthy of widespread clinical promotion in ICU VAP prevention and airway management.

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